Tramiprosate
CAS No. : 3687-18-1
(Synonyms: Homotaurine; 3-Amino-1-propanesulfonic acid)
| Size | Price | Stock |
|---|---|---|
| 5g | $16 | In-stock |
| 25g | $19 | In-stock |
| 100g | $45 | In-stock |
| 500g | $120 | In-stock |
| 1000g | $193 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-14602 |
| M.Wt: | 139.17 |
| Formula: | C3H9NO3S |
| Purity: | >98 % |
| Solubility: | H2O : 20 mg/mL (ultrasonic);DMSO : 1 mg/mL (ultrasonic) |
Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3]. In Vitro:Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane[1]. In Vivo:Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery[1].
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