AGN-195183
CAS No. : 367273-07-2
(Synonyms: IRX-5183; VTP-195183; NRX-195183)
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $450 | In-stock |
| 25mg | $900 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $2150 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16684 |
| M.Wt: | 437.86 |
| Formula: | C22H22ClF2NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 11 mg/mL (ultrasonic) |
AGN-195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN-195183 has no activity on RARβ/γ. IC50 & Target: IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans) In Vitro: AGN-195183 (IRX-5183; Compound 4) inhibits the growth of breast cancer cell lines, and is inactive in an in vivo model of topical irritation. AGN-195183 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3. AGN-195183 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580. AGN-195183 is currently in Phase I/IIA clinical trials in cancer patients.
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