AD-2646
CAS No. : 366487-89-0
(Synonyms: LCL102)
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| Cat. No. : | HY-124134 |
| M.Wt: | 408.57 |
| Formula: | C23H40N2O4 |
| Purity: | >98 % |
| Solubility: |
AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism[1][2].
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