EB-47
CAS No. : 366454-36-6
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|---|---|---|
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| Cat. No. : | HY-15046 |
| M.Wt: | 537.53 |
| Formula: | C24H27N9O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+?and extends from the nicotinamide to the adenosine subsite[1]. In Vitro: EB-47 shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0?μM, respectively[1]. In Vivo: EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation[3].
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