AY 9944
CAS No. : 366-93-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $880 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-107420 |
| M.Wt: | 464.30 |
| Formula: | C22H30Cl4N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic);H2O : 5 mg/mL (ultrasonic) |
AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3]. IC50 & Target:IC50: 13 nM (DHCR7)1 In Vitro:AY 9944 (1 μg/mL; 15 h) affects types of free sterol in keratinocytes[2]. In Vivo:AY 9944 (7.5 mg/kg; i.h. every 6 days once from postnatal day 2 to postnatal day 20) reduces brain cholesterol until 400 days after stop treatment[3].
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