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|---|---|---|
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| Cat. No. : | HY-124498 |
| M.Wt: | 216.28 |
| Formula: | C13H16N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Oxantel (CP-14445) is an anthelmintic agent that potently against Trichuris muris. Oxantel inhibits fumarate reductase (Frd) activity in some pathogenic bacteria and inhibits P. gingivalis homotypic biofilm formation (IC50 of 2.2 μM)[1][2].
IC50 & Target:nAChR[1][2]
In Vitro:Oxantel ( 0.015-600 μg/mL; 24-72 hours) reduces the viability of T. muris[1].
In Vivo:Oxantel (1-10 mg/kg; i.p.) displays a high activity against T. muris in vivo, with an EC50 of 4.71 mg/kg[1].
Oxantel (10 mg/kg; i.p.) exhibits a worm burden reduction (WBR) of 92.5% and worm expulsion rate (WER) of 88.4% for T. muris[1].
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