MCPA (sodium)

MCPA sodium is an orally active phenoxyacetic acid herbicide. MCPA sodium interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA sodium increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA sodium can be used to control broadleaf weeds^{[1][2][3][4][5]}. In Vitro: MCPA (50 μM) sodium is taken up by Caco-2 cells mainly via monocarboxylic acid transporters shared with benzoic acid and partially via L-lactic acid^[1].
MCPA (20-120 μM; 4 weeks) sodium inhibits growth of non-green potato tuber calli, disrupts membrane integrity, reduces energy charge, and affects redox state and antioxidant enzyme activities^[2].
In Vivo: MCPA (200 mg/kg/day; p.o.; 2 weeks) sodium increases hepatic cytochrome P-450 level and activities of aniline hydroxylase and 7-ethoxycoumarin O-deethylase in male rats^[4].
MCPA (¹⁴C-MCPA; 5-100 mg/kg; p.o.; single or multiple doses) sodium is rapidly absorbed and excreted mainly in urine in rats, with limited metabolism to HMCPA and glycine conjugate^[5].