Buspirone


CAS No. : 36505-84-7

36505-84-7
Price and Availability of CAS No. : 36505-84-7
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10mg $50 In-stock
25mg $98 In-stock
50mg $160 In-stock
100mg $250 In-stock
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Cat. No. : HY-B1115A
M.Wt: 385.50
Formula: C21H31N5O2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 36505-84-7 :

Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research[1]. In Vitro:The anxiolytic and anti-depressant effects of Buspirone are produced by activating 5-HT1A autoreceptors and 5-HT1A heteroreceptors, respectively[1].
Buspirone (0-400 µg/mL; 6 hours) has cytotoxic effect in lymphocytes[2].
Buspirone (0-180 µg/mL; 0-3 hours; lymphocytes) induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG)[2]. In Vivo:Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors[1].
Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores immobilization stress (IS)-shifted β-diversity in the gut microbiota[1].

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