N-p-trans-Coumaroyltyramine


CAS No. : 36417-86-4

36417-86-4
Price and Availability of CAS No. : 36417-86-4
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Cat. No. : HY-N2230
M.Wt: 283.33
Formula: C17H17NO3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 36417-86-4 :

N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC50: 122 μM) and α-glucosidase (IC50: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC50 of 13.3 µM against T. brucei rhodesiense. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease[1][2][3]. IC50 & Target:IC50: 122 μM (AChE)[2] In Vitro:N-p-trans-Coumaroyltyramine is cytotoxic to rat skeletal muscle myoblasts (L6 cells), with an IC50 of 105.3 μM[1].
N-p-trans-Coumaroyltyramine (0-120 μg/mL; 0-60 min) inhibits AChE activity in a dose-dependent manner, and the inhibition mode is reversible and mixed (competitive/non-competitive)[2].

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