Diazoxide
CAS No. : 364-98-7
(Synonyms: Sch-6783; SRG-95213)
| Size | Price | Stock |
|---|---|---|
| 1g | $58 | In-stock |
| 5g | $188 | In-stock |
| 10g | $308 | In-stock |
| 25g | $658 | In-stock |
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| Cat. No. : | HY-B1140 |
| M.Wt: | 230.67 |
| Formula: | C8H7ClN2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 35 mg/mL |
Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.
In Vitro: Diazoxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia[1].
Diazoxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage[2].
In Vivo: Diazoxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels[3].
Treatment with Diazoxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg[4].
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