C29
CAS No. : 363600-92-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | In-stock |
| 5mg | $130 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $391 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100461 |
| M.Wt: | 285.29 |
| Formula: | C16H15NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 30 mg/mL |
C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC50s of 19.7 and 37.6 μM, respectively[1].
IC50 & Target: TLR2[1]
In Vitro: C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells[1].
C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages[1].
C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages[1].
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