Phosphoramidon
CAS No. : 36357-77-4
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| Cat. No. : | HY-N2021 |
| M.Wt: | 543.50 |
| Formula: | C23H34N3O10P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively[1][2][3].
IC50 & Target:IC50: 0.4 μg/mL (Thermolysin)[2], 0.034 μM (NEP), 3.5 μM (ECE), 78 μM (ACE)[3]
In Vitro: Phosphoramidon (1-500 μM; 30 min) inhibits ET-converting enzyme (ECE) activity in a dose-dependent manner in solubilized rabbit lung membranes[5].
In Vivo: Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats[4].
Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats[5].
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