Columbamine
CAS No. : 3621-36-1
(Synonyms: Columbamin; Dehydroisocorypalmine)
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| Cat. No. : | HY-N0926 |
| M.Wt: | 338.38 |
| Formula: | C20H20NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 23 mg/mL |
Columbamine (Columbamin; Dehydroisocorypalmine) is an organic heterotetracyclic alkaloid extracted from plants. Columbamine is a metabolite of Berberine (HY-N0716). Columbamine inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM). Columbamine induces apoptosis in cancer cells. Columbamine can be used for antioxidant, anti-inflammatory, antitumor, antifungal, antiparasite, hepatoprotective, neuroprotective, hypolipidemic and hypoglycemic study[1][2][3][4][5].
IC50 & Target:IC50: 1.92 μM (P. falciparum)[1]
In Vitro: Columbamine (M2) (15 μM, 24 h) decreases the intracellular triglyceride (TG) contents in Hep G2 cells[2].
Columbamine (15 μM, 24 h) induces a reduction of lipid synthesis and increases in fatty acid oxidation mediated via AMPK activation in Hep G2 cells[2].
Columbamine (10-50 μM, 24-72 h) inhibits the proliferation of colon cancer cells via suppressing Wnt/β-catenin signaling pathway[4].
Columbamine (20-40 μM, 24 h) inhibits the invasion and migration of colon cancer cells[4].
Columbamine (20-40 μM, 48 h) triggers apoptosis by inhibiting a caspase-dependent mechanism in colon cancer cells[4].
In Vivo: Columbamine (5-20 mg/kg; 23 days) significantly decreases the tumor volumes in a dose-dependent manner in HCT116 xenograft mice model[4].
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