2-Hydroxyestradiol
CAS No. : 362-05-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $240 | In-stock |
| 10mg | $390 | In-stock |
| 25mg | $780 | In-stock |
| 50mg | $1250 | In-stock |
| 100mg | $2000 | In-stock |
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| Cat. No. : | HY-124489 |
| M.Wt: | 288.38 |
| Formula: | C18H24O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].
In Vitro: 2-Hydroxyestradiol induces phenotypical changes indicative of neoplastic transformation[1].
2-Hydroxyestradiol (2-OHE2) is capable of in vitro transforming a HBEC, MCF-10F cell line, that is estrogen receptor-a (ERα) negative and ERβ positive[1].
2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells[3].
In Vivo: 2-Hydroxyestradiol attenuated the development of obesity and improved endothelial function, decreased nephropathy, decreased the severity of diabetes, lowered arterial blood pressure, and reduced plasma cholesterol[2].
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