Kobusin
CAS No. : 36150-23-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $410 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N5101 |
| M.Wt: | 370.40 |
| Formula: | C21H22O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2]. In Vitro: Kobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells[1]. In Vivo: In charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice[1].
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