AS1604498
CAS No. : 361465-74-9
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| Cat. No. : | HY-119159 |
| M.Wt: | 319.36 |
| Formula: | C19H17N3O2 |
| Purity: | >98 % |
| Solubility: |
AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia[1].
In Vitro:AS1604498 (0.032-10 μM; 48 h) inhibits THP-1 human leukemia cell growth with an IC50 of 198 nM, and this effect is reversed by 10 mM Nicotinamide (HY-B0150)[1].
AS1604498 (0.032-10 μM; 48 h) inhibits K562 human chronic myelogenous leukemia cell growth with an IC50 of 673 nM, and this effect is reversed by 10 mM Nicotinamide[1].
AS1604498 (10 μM; 48 h) induces delayed caspase 3/7 activation in THP-1 cells, and this activation is reversed by 10 mM Nicotinamide[1].
AS1604498 (0.001-10 μM; 5 h) reduces intracellular NAD levels in K562 cells in a dose-dependent manner, and this effect is reversed by 10 mM Nicotinamide[1].
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