JDTic
CAS No. : 361444-66-8
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| Cat. No. : | HY-10486 |
| M.Wt: | 465.63 |
| Formula: | C28H39N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
JDTic is a blood-brain barrier-permeable κ-opioid receptor antagonist (Ki=0.02 nM) with favorable in vitro ADME properties. JDTic blocks agonist-mediated Gi and β-arrestin signaling pathways as well as analgesic effects by stabilizing the inactive conformation of hKOR and activating JNK. JDTic may also induce transient asymptomatic ventricular tachycardia. JDTic is widely applicable to studies related to depression, anxiety, stress-induced addictive behaviors, and nicotine withdrawal[1][2][3].
In Vitro:JDTic has a Ki value of 0.02 nM for the κ receptor, with 1255-fold selectivity over the μ receptor and 3800-fold selectivity over the δ receptor[1].
JDTic inhibits binding to the human hERG potassium channel, with a Ki value of 8.820 μM[1].
JDTic shows no agonist activity in HEK293-T cells and can completely inhibit the signaling pathway induced by U69593[3].
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