Fluoxastrobin

Fluoxastrobin is a fungicide. By binding to NAD-dependent epimerase/dehydratase, Fluoxastrobin interferes with electron transport, reduces ATP production and inhibits mycelial growth, thereby effectively controlling foliar diseases of tea plants. Fluoxastrobin induces oxidative stress by increasing ROS levels and lipid peroxidation, causes DNA damage and promotes apoptosis; meanwhile, it shows high acute toxicity to Danio rerio embryos and larvae. Fluoxastrobin can be used in research related to tea foliar diseases (including tea red leaf spot and tea gray leaf spot)^[1][2]. In Vitro:Fluoxastrobin (13.64 μg/mL) inhibits Pestalotiopsis trachicarpicola hyphal growth with an in vitro half-maximal effective concentration of 13.64 μg/mL, disrupts fungal energy metabolism via dose-dependent inhibition of ATP production and elevation of hyphal membrane potential, and binds stably to the fungal NAD-dependent epimerase/dehydratase^[2]. In Vivo:Fluoxastrobin (0.03-1.0 mg/L; aqueous immersion; static, daily semi-static refresh; 72-144 hours) exhibits high acute toxicity to Danio rerio embryos (96 h LC₅₀ = 0.549 mg/L) and induces dose-dependent delayed hatching, teratogenicity, developmental impairment, oxidative stress, and DNA damage^[1].