Cholic acid (sodium)
CAS No. : 361-09-1
(Synonyms: Sodium cholate)
| Size | Price | Stock |
|---|---|---|
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| 10g | $50 | In-stock |
| 25g | $95 | In-stock |
| 50g | $150 | In-stock |
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| Cat. No. : | HY-N0324A |
| M.Wt: | 430.55 |
| Formula: | C24H39NaO5 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 250 mg/mL |
Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active[1][2]. In Vitro: Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1]. In Vivo: Cholic acid (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity[2].
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