Dihydrosanguinarine

Dihydrosanguinarine (13,14-Dihydrosanguinarine) is an alkaloid with antibacterial and anti-inflammatory activities, and also an important precursor of Sanguinarine (HY-N0052). Dihydrosanguinarine targets and regulates the TNF/IL-17/PI3K signaling pathway, downregulates the levels of pro-inflammatory factors such as IL-17A, TNF-α and IL-6, upregulates the expression of TGF-β, inhibits myeloperoxidase activity, and regulates the transcription of multiple inflammation-related genes. Dihydrosanguinarine exhibits antibacterial activity against a variety of oral microorganisms. Dihydrosanguinarine can be used in research related to liver inflammation and oral flora dysbiosis^[1][2]. In Vitro:Dihydrosanguinarine shows antibacterial activity against oral aerobic and anaerobic microorganisms with a minimum inhibitory concentration of 140-150 μg/mL^[1]. In Vivo:Dihydrosanguinarine (10-20 mg/kg) protects against LPS-triggered hepatitis in male BALB/c mice by reducing inflammatory pathology, modulating key cytokine levels, and regulating mRNA expression of inflammation-related genes^[2].