A-317920
CAS No. : 360551-59-3
| Size | Price | Stock |
|---|---|---|
| 100 mg | Get quote | |
| 250 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-122171 |
| M.Wt: | 453.53 |
| Formula: | C25H31N3O5 |
| Purity: | >98 % |
| Solubility: |
A-317920 is a selective and potent rat histamine H3 receptor (H3R) antagonist with pKi value of 9.2 and 7.0 for full-length rat and full-length human H3R, respectively. A-317920 exhibits over 130 fold selective affinity for the rat over the human H3R. A-317920 enhances cognition via H3R blockade[1].
In Vitro:A-317920 is a potent antagonist at rat H3R in reversing R-α-methylhistamine [(R)-α-MeHA] inhibition of Forskolin-stimulated cAMP formation (pKb value of 9.1) but a weak antagonist at human H3R in cyclase (pKb value of 6.3) and calcium mobilization (pKb value of 7.3) assays in cells co-expressing Galphaqi5-protein[1].
A-317920 potently antagonizes native H3Rs by blocking histamine inhibition of potassium-evoked [3H]histamine release from rat brain cortical synaptosomes (pKb value of 9.3) and (R)-α-MeHA reversal of electric field-stimulated guinea pig ileum contractions (pA2 value of 8.3)[1].
In Vivo:A-317920 (3-10 mg/kg; s.c; 30 min prior to training; for a total of five trials) significantly improves in the avoidance test in spontaneously hypertensive rat (SHR) pups[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- A-317920
- Cat. No.:
- HY-122171
- Quantity:
Your information is safe with us.