Desglymidodrine
CAS No. : 3600-87-1
(Synonyms: ST 1059)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $150 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $380 | In-stock |
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| Cat. No. : | HY-114794 |
| M.Wt: | 197.23 |
| Formula: | C10H15NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Desglymidodrine (ST 1059), the active metabolite of Midodrine (HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2].
In Vitro: Desglymidodrine (ST 1059) (1-1000 μM) affects vein contraction with the pD2 values (negative logarithm of the concentration which causes 50% of the maximum possible effect) of 4.64 (-log mol/L) in dog isolated femoral veins and 4.48 (-log mol/L) in isolated human saphenous veins, respectively[1].
Desglymidodrine (ST 1059) acts on α1A, α1B, α1D in rat and α2A in human adrenoceptor with the pKi values of 5.89, 5.16, 5.78 and 5.83, respectively[2].
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