DNA2 inhibitor C5
CAS No. : 35973-25-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $71 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $670 | In-stock |
| 100mg | $930 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-128729 |
| M.Wt: | 234.17 |
| Formula: | C10H6N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 31.25 mg/mL (ultrasonic) |
DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research[1].
IC50 & Target:IC50: 20 μM (DNA2 nuclease)[1]
In Vitro:DNA2 inhibitor C5 (0-250 μM) inhibits the nuclease activity of DNA2[1].
DNA2 inhibitor C5 (0-10 μM) has a strong synergistic effect in inhibiting MCF7 cell survival with MK4827, with IC50 values of 0.8 μM and 1.9 μM respectively and a combination index of 0.13[1].
In Vivo:DNA2 inhibitor C5 shows synthetic lethality with deficiencies in FEN1, EXO1, or MRE11 genes in the mouse model with HCT116fox/- cells carrying a conditional genetic knockout of DNA2[1].
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