Drinabant
CAS No. : 358970-97-5
(Synonyms: AVE1625)
| Size | Price | Stock |
|---|---|---|
| 1mg | $90 | In-stock |
| 5mg | $195 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $495 | In-stock |
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| Cat. No. : | HY-14788 |
| M.Wt: | 497.38 |
| Formula: | C23H20Cl2F2N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Drinabant (AVE1625) is an orally active CB1 receptor antagonist. Drinabant (AVE1625) inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R[1].
In Vivo: AVE1625 (10 mg/kg orally once daily), combined with Olanzapine (HY-14541) attenuates body weight gain, diminishing the enhanced food intake while maintaining increased energy expenditure and decreased motility[2].
AVE1625 (1, 3, and 10 mg/kg ip), reverses abnormally persistent LI induced by MK-801 (HY-15084B) or neonatal nitric oxide synthase inhibition in rodents, and improves both working and episodic memory[3].
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