UBCS039
CAS No. : 358721-70-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $980 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-115453 |
| M.Wt: | 247.29 |
| Formula: | C16H13N3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1].
IC50 & Target:EC50: 38 μM (SIRT6)[1].
In Vitro:UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells[2].
UBCS039 leads to autophagosome accumulation in human cancer cells[2].
UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation[2].
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