Dipyridamole (hydrochloride)(1:x)
CAS No. : 35763-39-4
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| Cat. No. : | HY-B0312A |
| M.Wt: | 1000.00 |
| Formula: | C24H40N8O4.xClH |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Dipyridamole is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole also can induce cancer cell-specific apoptosis as a phosphodiesterase (PDE) inhibitor[1][2]. IC50 & Target: PDE In Vitro: Dipyridamole inhibits the cAMP hydrolysis may because of synergizing with statins to induce cancer cell death. The statin dipyridamole combination can induce apoptosis in primary AML cells. Dipyridamole possessecAMP/PKA-independent activity against statininduced SREBP2 activation[2]. In Vivo: Dipyridamole mitigates tumor growth, ameliorated concurrent alterations in blood circulation and tumor tissues, and platelet infiltration in tumor tissues[3].
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