2-Thio-UTP
CAS No. : 35763-29-2
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| Cat. No. : | HY-116307 |
| M.Wt: | 500.21 |
| Formula: | C9H15N2O14P3S |
| Purity: | >98 % |
| Solubility: |
2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) [1][2]. In Vitro:2-Thio-UTP (10 µM; 5 days) reduces the mRNA expression of ACTA2, TGFB1, TGFB2, COL1A1, COL3A1 and reduces the protein of αSMA in valve interstitial cells[2].
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