NNC 55-0396


CAS No. : 357400-13-6

(Synonyms: NNC 55-0396 dihydrochloride)

357400-13-6
Price and Availability of CAS No. : 357400-13-6
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1mg $76 In-stock
5mg $160 In-stock
10mg $260 In-stock
50mg $700 In-stock
100mg $1135 In-stock
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Cat. No. : HY-50722
M.Wt: 564.56
Formula: C30H40Cl2FN3O2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 357400-13-6 :

NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC50 value of 6.8 μM for Cav3.1 T-type channels. NNC 55-0396 can be used for the research of neurological disease research[1][2]. In Vitro:NNC 55-0396 (0.1-1000 μM) shows no inhibition to the HVA Ca2+ currents in INS-1 cells[1].
NNC 55-0396 (1-100 μM) blocks more than 50% of the T-type Ca2+ current at 8 μM in HEK 293/α1G cells[1].
NNC 55-0396 blocks T-type Ca2+ current with an IC50 value of 6.8 μM[1]. In Vivo:NNC 55-0396 (20 mg/kg; i.p. once) suppresses tremor in GABAA subunit α1-null mice and harmaline mouse models[1].

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