Bupropion morpholinol


CAS No. : 357399-43-0

357399-43-0
Price and Availability of CAS No. : 357399-43-0
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Cat. No. : HY-12766
M.Wt: 255.74
Formula: C13H18ClNO2
Purity: >98 %
Solubility: DMSO : 20 mg/mL (ultrasonic;warming);Ethanol : 20 mg/mL (ultrasonic;warming)
Introduction of 357399-43-0 :

Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities[1][2][3]. IC50 & Target:Dopamine transporter[2], Norepinephrine transporter[2], α4β2 nicotinic receptor[2] In Vitro: Bupropion morpholinol is produced from Bupropion by the genetically polymorphic enzyme CYP2B6 in vivo[1].
Bupropion morpholinol inhibits [3H]norepinephrine uptake with an IC50 of 1.7 μM[2].

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