Barbadin
CAS No. : 356568-70-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $65 | In-stock |
| 2mg | $114 | In-stock |
| 5mg | $192 | In-stock |
| 10mg | $307 | In-stock |
| 25mg | $645 | In-stock |
| 50mg | $1032 | In-stock |
| 100mg | $1650 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-119706 |
| M.Wt: | 333.41 |
| Formula: | C19H15N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1?μM for β-arrestin1 and 15.6?μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis[1][2].
IC50 & Target:IC50: 19.1 μM (β-arrestin1); 15.6 μM (β-arrestin2)[1]
In Vitro: Barbadin (4 h) treatment reduces cell viability and induces apoptosis[2].
Barbadin (2 h) treatment arrests breast cancer cells in G0/G1 phase[2].
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