SB 525334
CAS No. : 356559-20-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $108 | In-stock |
| 25mg | $226 | In-stock |
| 50mg | $372 | In-stock |
| 100mg | $570 | In-stock |
| 200mg | $800 | In-stock |
| 500mg | $1315 | In-stock |
| 1g | $1710 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-12043 |
| M.Wt: | 343.42 |
| Formula: | C21H21N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM. IC50 & Target: IC50: 14.3 nM (ALK5)[1] In Vitro: SB525334 (1 μM; for 15 minutes before stimulating with 0.625 ng/ml of TGF-β1, assesses after 6 days) inhibits TGF-β1-mediated proliferation of familial idiopathic pulmonary arterial hypertension (iPAH) pulmonary artery smooth muscle cells (PASMCs) at an IC50 of 295 nM [2]. In Vivo: SB525334 (3-30 mg/kg; p.o.; daily from days 17 to 35) significantly reverses pulmonary arterial pressure in a rat model of pulmonary arterial hypertension (PAH)[2].
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