Belimumab
CAS No. : 356547-88-1
(Synonyms: LymphoStat B)
| Size | Price | Stock |
|---|---|---|
| 1mg | $72 | In-stock |
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $640 | In-stock |
| 100mg | $1025 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-P9952 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research[1][2][3][4]. The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.
IC50 & Target:TNFSF13B/BAFF/CD257
In Vivo:Belimumab (5, 15 or 50 mg/kg, i.v., once every 2 weeks for 13 or 26 weeks) decreases CD20+ B lymphocytes in the peripheral blood in cynomolgus monkeys[3].
Single-Dose Pharmacokinetics of i.v. Belimumab in Cynomolgus Monkeys[3]
| Parameters | Cmax (μg/mL) | AUC0-∞ (day μg/mL) | V1 (mL/kg) | Vss (mL/kg) | CL (mL/day/kg) | T1/2,α (day) | T1/2,term (day) | MRT (day) |
| 5 mg/kg (n=4) | 111±2 | 901±40 | 45.0±0.7 | 85.0±2.1 | 5.6±0.2 | 0.52±0.13 | 11.2±0.7 | 15.4±1.0 |
| 50 mg/kg (n=3) | 1230±180 | 8970±320 | 42.4±5.9 | 108±14 | 5.6±0.2 | 0.44±0.20 | 14.0±1.8 | 19.1±2.1 |
| 150 mg/kg (n=3) | 3778±326 | 22,693±3990 | 39.7±3.3 | 89.8±11.4 | 6.8±1.3 | 0.41±0.55 | 11.5±1.7 | 13.7±3.5 |