Ani9
CAS No. : 356102-14-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $345 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $980 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-119981 |
| M.Wt: | 332.78 |
| Formula: | C17H17ClN2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors[1][2][3].
In Vitro:Ani9 (0-30 μM, 20 min) does not affect the increase of cytoplasmic calcium induced by ATP in FRT cells[1].
Ani9 (1-10 μM, 20 min) inhibits ANO1[1].
Ani9 (0.03-10 μM, 20 min) inhibits CaCC current in PC3, Capan-1, and NHNE cells in a dose-dependent manner, with an IC50 of 110 nM[1].
Ani9 (0-10 μM, 24 h) highly expresses ANO1 in PC3 cells[2].
Ani9 (0.01-10 μM, 48 h) inhibits weakly in prostate cancer, breast cancer, and pancreatic cancer cells[2].
Ani9 (1 μM) inhibits Ca2+-activated Cl- (Clca) in portal vein smooth muscle of Cav1-KO mice[3].
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