3-Aminobenzamide
CAS No. : 3544-24-9
(Synonyms: PARP-IN-1)
| Size | Price | Stock |
|---|---|---|
| 1g | $8 | In-stock |
| 5g | $24 | In-stock |
| 10g | $31 | In-stock |
| 25g | $76 | In-stock |
| 100g | $268 | In-stock |
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| Cat. No. : | HY-12022 |
| M.Wt: | 136.15 |
| Formula: | C7H8N2O |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 11.11 mg/mL |
3-Aminobenzamide (PARP-IN-1) is a potent inhibitor of?PARP?with?IC50?of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion. IC50 & Target: IC50: 50 nM (PARP)[1] In Vitro: 3-Aminobenzamide (PARP-IN-1) (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions[1].?3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H2O2[2]. In Vivo: In a db/db (Leprdb/db) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion[3]. 3-Aminobenzamide (1.6 mg/kg via intracerebral injection) prevents NAD+ depletion and improves water maze performance after controlled cortical impact (CCI) in mice[4].
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Inquiry Information- Product Name:
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- Cat. No.:
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