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|---|---|---|
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| 500 mg | Get quote | |
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| Cat. No. : | HY-113243 |
| M.Wt: | 521.67 |
| Formula: | C26H52NO7P |
| Purity: | >98 % |
| Solubility: |
1-Oleoyl lysophosphatidylcholine is a GPR119 activator and insulin secretion potentiator with a human GPR119 EC50 of 1.5 μM.1-Oleoyl lysophosphatidylcholine acts as a bioactive lipid mediator with diverse physiological and pathological functions.1-Oleoyl lysophosphatidylcholine can be used for the research of diabetes[1].
In Vitro:1-Oleoyl lysophosphatidylcholine (1-10 μM; 15-25 min) dose-dependently induces intracellular cAMP accumulation and insulin secretion in NIT-1 mouse pancreatic β-cells via adenylate cyclase activation, with significant effects observed at concentrations ≥3 μM[1].
1-Oleoyl lysophosphatidylcholine (15 min) activates human GPR119 in RH7777 rat hepatoma cells, inducing dose-dependent intracellular cAMP accumulation with an EC50 of 1.5 μM[1].
1-Oleoyl lysophosphatidylcholine induced insulin secretion in NIT-1 mouse pancreatic β-cells is at least partially mediated by GPR119, as demonstrated by reduced secretion following siRNA-mediated knockdown of GPR119[1].
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