1-Oleoyl lysophosphatidylcholine


CAS No. : 3542-29-8

3542-29-8
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Cat. No. : HY-113243
M.Wt: 521.67
Formula: C26H52NO7P
Purity: >98 %
Solubility:
Introduction of 3542-29-8 :

1-Oleoyl lysophosphatidylcholine is a GPR119 activator and insulin secretion potentiator with a human GPR119 EC50 of 1.5 μM.1-Oleoyl lysophosphatidylcholine acts as a bioactive lipid mediator with diverse physiological and pathological functions.1-Oleoyl lysophosphatidylcholine can be used for the research of diabetes[1]. In Vitro:1-Oleoyl lysophosphatidylcholine (1-10 μM; 15-25 min) dose-dependently induces intracellular cAMP accumulation and insulin secretion in NIT-1 mouse pancreatic β-cells via adenylate cyclase activation, with significant effects observed at concentrations ≥3 μM[1].
1-Oleoyl lysophosphatidylcholine (15 min) activates human GPR119 in RH7777 rat hepatoma cells, inducing dose-dependent intracellular cAMP accumulation with an EC50 of 1.5 μM[1].
1-Oleoyl lysophosphatidylcholine induced insulin secretion in NIT-1 mouse pancreatic β-cells is at least partially mediated by GPR119, as demonstrated by reduced secretion following siRNA-mediated knockdown of GPR119[1].

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