BRD2577
CAS No. : 353781-42-7
| Size | Price | Stock |
|---|---|---|
| 100mg | $323 | In-stock |
| 250mg | $547 | In-stock |
| 1g | $1471 | In-stock |
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| Cat. No. : | HY-114804 |
| M.Wt: | 317.36 |
| Formula: | C15H15N3O3S |
| Purity: | >98 % |
| Solubility: |
BRD2577 is a selective mercaptopyruvate sulfurtransferase (3-MST) inhibitor with an IC50 of 9.9 μM. BRD2577 inhibits H2S production in colon carcinoma cells. BRD2577 exhibits weak to no significant inhibitory effect on colon cancer cell proliferation and mitochondrial activity. BRD2577 can be used for the research of colon cancer[1].
In Vitro:BRD2577 (Compound 13a) (3-300 μM; 1 h) potently inhibits recombinant human 3-MST with an IC50 of 9.9 μM and achieves ≥60% inhibition at 100 μM, and shows no activity against human recombinant CBS or CSE at concentrations up to 300 μM[1].
BRD2577 (300 μM; 2 h) does not act as an H2S scavenger at 300 μM, confirming its inhibitory effect is direct against 3-MST[1].
BRD2577 (300 μM; 4 h) inhibits H2S production in live murine CT26 and MC38 colon carcinoma cells[1].
BRD2577 (3-300 μM; 48 h) does not significantly inhibit the proliferation of murine CT26 or MC38 colon carcinoma cells at concentrations up to 300 μM after 48 h of treatment[1].
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