Ompenaclid
CAS No. : 353-09-3
(Synonyms: RGX-202; 3-Guanidinopropionic acid)
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|---|---|---|
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| 100g | $40 | In-stock |
| 500g | $126 | In-stock |
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| Cat. No. : | HY-W015828 |
| M.Wt: | 131.14 |
| Formula: | C4H9N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : ≥ 50 mg/mL |
Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy[1][2]. In Vitro: Ompenaclid (RGX-202; 10 μM; 96 hours) reduces cell growth, and reveals a nearly complete depletion of phosphocreatine (>99%), greater than 79% reduction in cellular creatine and a substantial (46%) reduction in intracellular ATP levels relative to control cells in hypoxia[1]. In Vivo: Ompenaclid (RGX-202; 800 mg/kg; p.o. for 35 days) reduces UN-KPC-961 pancreatic tumoral creatine levels in B6129SF1/J mice[1].
Ompenaclid (approximately 650 mg/kg; i.p. daily for 14 days) treatment reduces Lvm3b cells liver metastatic colonization by eightfold in NOD-SCID mice[1].
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