PAR-4 Agonist Peptide, amide
CAS No. : 352017-71-1
(Synonyms: PAR-4-AP; AY-NH2)
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| 5mg | $180 | In-stock |
| 10mg | $300 | In-stock |
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| Cat. No. : | HY-P1309 |
| M.Wt: | 680.79 |
| Formula: | C34H48N8O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. IC50 & Target:PAR-4[1] In Vivo: Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) [1].
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