SB-423557
CAS No. : 351490-26-1
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| Cat. No. : | HY-15106 |
| M.Wt: | 464.60 |
| Formula: | C28H36N2O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation[1]. IC50 & Target: IC50: 520 nM (Calcium-sensing receptor)[1] In Vivo: SB-423557 (oral administration; 10, 30 or 100 μM/kg; once daily; 12 weeks) elicits transient increases in plasma concentrations of PTH, resulting in increased bone mass and strength in both vertebrae and long bones compared to that of OVX controls[1].
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