H1PVAT
CAS No. : 351438-49-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-12349 |
| M.Wt: | 417.42 |
| Formula: | C19H14F3N5OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
H1PVAT is a potent and selective inhibitor of poliovirus serotypes (PV-1, PV-2, PV-3), and inhibits early stage of the replication. H1PVAT interacts with viral capsid directly and protects PV against heat inactivation[1][2].
IC50 & Target: EC50: 10 nM (PV-1), 26 nM (PV-2), 218 nM (PV-3)[1]
In Vitro: H1PVAT (10-218 nM; 24-48 h) inhibits poliovirus strain Sabin replication in a dose-dependent manner, with EC50s of 10 nM (PV-1), 26 nM (PV-2) and 218 nM (PV-3), respectively[1].
H1PVAT (30 min prior to or 1 h after PV-1 infection; 7 h) inhibits an early stage of viral replication , and only H1PVAT is administered prior to infection results reduction (>99.9%) in intracellular viral RNA levels[1].
H1PVAT (50 μM; 2 min) protects PV against heat inactivation with the 50% thermal inactivation temperature increased to 52.6 ℃ and 50.8 ℃, which suggests a direct interaction between the viral capsid and H1PVAT[1].
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