Nemorosone
CAS No. : 351416-47-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $103 | In-stock |
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| Cat. No. : | HY-121458 |
| M.Wt: | 502.68 |
| Formula: | C33H42O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].
IC50 & Target: apoptosis[1]
In Vitro: Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines[1].
In Vivo: Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2].
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