Akuammine
CAS No. : 3512-87-6
(Synonyms: (-)-Akuammine; Vincamajoridine)
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| Cat. No. : | HY-122189 |
| M.Wt: | 382.45 |
| Formula: | C22H26N2O4 |
| Purity: | >98 % |
| Solubility: |
Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.
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