TGX-115
CAS No. : 351071-62-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $388 | In-stock |
| 5mg | $927 | Get quote |
| 10mg | $1284 | Get quote |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-124535 |
| M.Wt: | 336.38 |
| Formula: | C20H20N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated PI(3,4)P2 and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus[1][2].
In Vitro:TGX-115 (0.1-10 μM, 6 h) blocks Akt (Ser473) phosphorylation but exerts no dose-dependent effect on Erk (Thr202/204) phosphorylation in U373MG glioma cells[1].
In Vivo:TGX-115 (10 mg/kg, i.p., single dose) has no effect on insulin-induced blood glucose reduction in 4-month-old FVB/N female mice[1].
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