OGG1-IN-08
CAS No. : 350997-39-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $450 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-112902 |
| M.Wt: | 261.13 |
| Formula: | C9H6Cl2N2OS |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1[1]. IC50 & Target: IC50: 0.22 μM (OGG1)[1] In Vitro: OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits?nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively[1].OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control[1].OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor[1].
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