Cercosporin

Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations^[1]. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC₅₀ of 0.6-1.3 μM^[2]. IC50 & Target:IC50: 0.6-1.3 μM (PKC)^[2] In Vitro: Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD₅₀ value for the T98G cells (0.14 J cm²) is much less than the LD₅₀ value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm², respectively)^[1].
Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells^[1].