UK-383367
CAS No. : 348622-88-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $147 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $860 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13102 |
| M.Wt: | 324.38 |
| Formula: | C15H24N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 65 mg/mL (ultrasonic;warming) |
UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring[1][2][3].
In Vitro:UK-383367 (100-1000 nM, 24 h) inhibits the activity of NRK-49F cells[1].
UK-383367 (100-200 nM, 30 min) effectively suppresses the fibrotic response induced by TGF-β1 in mPTCs cells and shows a direct anti-fibrotic effect on renal cells in NRK-49F cells[1].
In Vivo:UK-383367 (5 mg/kg, intraperitoneal injection, once daily for seven days) improves tubulointerstitial fibrosis and inflammation in unilateral ureteral obstruction (UUO) chronic kidney disease (CKD) mice[1].
Pharmacokinetics of single intravenous and oral administration in rats and dogs[2]
| Animal | Intravenous dose (mg/kg) | Elimination half-life (h) | Plasma clearance (mL/min•kg) | Volume of distribution (1/kg) | Oral dose (mg/kg) | Cmax (ng/mL) | Tmax (h) | Oral bioavailability (%) |
| Male rat | 2.0 | 0.8 | 157 | 12.0 | / | / | / | / |
| Male dog | 0.5 | 1.5 | 35 | 4.6 | 2 | 110 | 0.5-1.5 | 13 |