Pritelivir
CAS No. : 348086-71-5
(Synonyms: AIC316; BAY 57-1293)
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $52 | In-stock |
| 25mg | $100 | In-stock |
| 50mg | $150 | In-stock |
| 100mg | $250 | In-stock |
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| Cat. No. : | HY-15303 |
| M.Wt: | 402.49 |
| Formula: | C18H18N4O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 33 mg/mL |
Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2[1].
IC50 & Target: IC50: 0.02 μM (HSV1-2)[1]
In Vivo: Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase-primase enzyme complex[2].
Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis[3].
Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS[3].
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