ITX3
CAS No. : 347323-96-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $74 | In-stock |
| 10mg | $134 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16663 |
| M.Wt: | 371.45 |
| Formula: | C22H17N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic;warming;heat to 80°C) |
ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of drug[1][2]. IC50 & Target: IC50: 76 μM (TrioN)[1] In Vitro: ITX3 (5, 10, 25, 50 and 100 μM; 24 h) inhibits TrioN signaling[1]. ITX3 (50 μM; 1 h) specifically inhibits TrioN[1]. ITX3 (100 μM; 36 h) inhibits nerve growth factor-induced neurite outgrowth in PC12 cells[1]. ITX3 (1, 10 and 100 μM) represses Rac1 activity and dose-dependently up-regulates the E-cadherin protein level and phospho-p38 signal in Tara-KD cells[2].
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