AMP-PCP
CAS No. : 3469-78-1
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| Cat. No. : | HY-106723 |
| M.Wt: | 505.21 |
| Formula: | C11H18N5O12P3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1]. In Vitro: AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].
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