DC260126
CAS No. : 346692-04-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $84 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $288 | In-stock |
| 100mg | $460 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101906 |
| M.Wt: | 307.38 |
| Formula: | C16H18FNO2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively)[1]. DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis[2]. In Vitro: DC260126 reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells, suppresses palmitic acid potentiated glucose-stimulated insulin secretion, and negatively regulates GPR40 mRNA expression induced by oleic acid in Min6 cells[1].
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